With MicroProbes' novel and reliable products the photoactivation/photoinhibition of cells through an integrated optical fiber combined with multichannel arrays allow you to achieve neural electrophysiological recording of an extended brain area in parallel with photostimulation.
Designed for chronic experiments, the Microprobes Optogenetics Microwire Array (Opto-MWA) provides the optimum in flexibility and affordable alternative for the neuroscience community.
Features
Multiple optical fiber diameter available.
Up to 32 penetrating wires per array for short- and long-term recording.
Custom wire length (5 - 23 mm), including different length for each row.
Custom spacing between electrodes is in the range of 0.1 - 1 mm
Custom spacing between wires is in the range of 250 - 1000 µm.
Custom wire diameter options available (25 / 50 µm).
Impedance options between 200-800 kΩ.
Stainless Steel and Platinum/Iridium fine wires teflon or polyimide insulation material.
Custom reference and ground electrode according to the researcher's requirements.
Photoexcitation and -inhibition
photoexcitation
photoinhibition
The small-scale but high-density arrays provide multichannel Single-Unit (SUA), Multi-Unit (MUA) and Field Potential (FP) data leading to consistent and high-quality results.
Standard Layouts
Layout I. (Top view)Layout II. (Top view)Layout III. (Top view)Layout IV. (Top view)
Wire diameter 25 µm and 50 µm
A. Distance between wires 100 µm to 1 mm
B. Distance between wire to fiber optic 100 µm to 1 mm
C. Fiber Optic diameter 125 µm or 230 µm
References:
Sensory-motor circuits and Optogenetics Data provided (to MicroProbes) by Ilka Diester, Ernst Strüngmann Institute, Frankfurt (Main).
Recording of an optically stimulated neuron expressing channel rhodopsin (CHR2) in the striatum of a mouse using a custom Opto Micro-Wire array. A. RASTER and PETH of striatal spikes generated using 1ms pulses of 473 nm blue laser light. B. Waveforms of spikes from A, plotted in relation to the onset and offset of the laser pulse. C. Spike fidelity is linearly correlated to laser output intensity. Courtesy (to MicroProbes) of Mark O. West’s Lab at Rutgers University.
How to order:
Please contact the manufacturer, MicroProbes directly for further specifications and ordering. We would appreciate if you mention "Science Products" at any order or inquiry.
