With MicroProbes' novel and reliable products the photoactivation/photoinhibition of cells through an integrated optical fiber combined with multichannel arrays allow you to achieve neural electrophysiological recording of an extended brain area in parallel with photostimulation.
Features
Multiple optical fiber diameter available.
Up to 32 penetrating electrodes surrounding one or more optical fiber.
Custom length of each electrode and optical fibers between 1 to 40 mm, including different lengths within the array.
Custom spacing between electrodes is in the range of 0.1 - 1 mm
Custom microelectrode impedance for individual electrodes ranges between 10 kΩ - 5 MΩ.
Custom electrode tip diameter between 1 - 6 µm.
Custom reference and ground electrodes according to the researcher’s requirements.
Optionally integrated fiber optic and/or drug delivery cannula.
Parylene-C electrode insulation.
Pure Iridium is suggested for chronic stimulation studies.
The fiber optic is positioned in the middle of the array, its vertical position is custom and its receptacle is compatible with most of the light sources.
Photoexcitation and -inhibition
photoexcitation
photoinhibition
The small-scale but high-density arrays provide multichannel Single-Unit (SUA), Multi-Unit (MUA) and Field Potential (FP) data leading to consistent and high-quality results.
Standard Layouts
Layout I. (Top view)Layout II. (Top view)Layout III. (Top view)Layout IV. (Top view)
Electrode diameter 75 µm, 125 µm and 225 µm
A. Distance between electrodes 100 µm to 1 mm
B. Distance between electrode to fiber optic 100 µm to 1 mm
C. Fiber Optic diameter 125 µm or 230 µm
References:
Optogenetics combines genetic targeting of specific neurons or proteins with optical technology for imaging or control of the targets within intact, living neural circuits. (Deisseroth et al., Next-generation optical technologies for illuminating genetically targeted brain circuits. J. Neurosci.2006 Oct 11; 26 (41): 10380-6.)Sensory-motor circuits and Optogenetics Data provided (to MicroProbes) by Ilka Diester, Ernst Strüngmann Institute, Frankfurt (Main).
How to order:
Please contact the manufacturer, MicroProbes directly for further specifications and ordering. We would appreciate if you mention "Science Products" at any order or inquiry.
